Follistatin (Follistatin-344) (also known as an activin-binding protein) is an autocrine glycoprotein that is formed in virtually all tissues of the body. Follistatin is encoded by the FST gene.
For the first time, follistatin was isolated from the follicular fluid (hence the name), after which it was determined that it is able to inhibit the follicle-stimulating hormone in the anterior lobe of the pituitary gland. This is due to the binding to the protein of the activator, which in turn stimulates the secretion of the follicle-stimulating hormone.
Contrary to popular belief, follistatin does not cause hypertrophy of the myocardium
Importance in bodybuilding
Experiments on animals demonstrated that the introduction of follistatin leads to an increase in muscle mass and muscle strength in healthy animals, and in dystrophic mice, muscle pathology undergoes reverse development, even in the case of older individuals. Follistatin acts as a blocker of myostatin.
A significant disadvantage of using follistatin as a blocker of myostatin is its low specificity, since it also suppresses the function of activins, which regulate the growth and differentiation of almost all cell types, including cells of the gonads, pituitary gland and skeletal muscles.
For this reason, scientists have developed a myostatin inhibitor FS I-I, derived from follistatin and a specific myostatin. The transgenic mice expressing this peptide possessed an increased mass and strength of muscles. These results indicate the therapeutic potential of FS I-I in muscular dystrophies and sarcopenia.
The latest trials, which ended in 2009 on monkeys, showed that genetic regulation of the level of follistatin gives tangible results in muscle growth and increased strength. These data pushed scientists to clinical trials in humans, which, according to preliminary data, were to begin in the summer of 2010.
In 2013, Follistatin-344 appeared on sale through the network. Prices from retail distributors are approximately 2-3 thousand rubles per 1000 micrograms.
- Increasing strength
- Muscle growth
- Increased appetite, in some cases suppression
- Increase of efficiency
- Fat burning, by stimulating the metabolism of brown fat cells
Sellers recommend taking Follistatin-344 according to the scheme: 100 mcg per day, subcutaneously, for 10-20 days. It is usually used for a set of dry muscle mass or on drying (there is a rapid growth of up to 4 kg in 10 days), this peptide also significantly increases the strengths. Follistatin-344 seems to be a promising tool in powerlifting, as it does not appear on doping control. There may be redness at the injection site.
Follistatin has a direct effect on folliculogenesis, so theoretically, women may have complications. According to the literature, the FST plays a role in the development of polycystic ovary.