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Tamoxifen 20

Tamoxifen 20

Tamoxifen 20

Brand :Sun Rise
Product Code :626
Availability :In Stock
Package: 20 mg/tab. (10 tab.)
Substance: tamoxifen citrate
  • £4.56

Buy Tamoxifen 20 mg UK Online

Tamoxifen 20 mg displays antitumor effect due to its antiestrogenic activity (ER). Values for the apparent affinity of Tamoxifen for the ER range between 30 and 0.01% of that obtained for estradiol, dependent on different ER source (species), protein concentration and condition used for assay. Binding of Tamoxifen to ER further leads to inhibition expression of estrogen-regulated genes, including growth factors and angiogenic factors secreted by the tumor that may stimulate growth by autocrine or paracrine mechanisms. Tamoxifen also directly induces programmed cell death. [1]

Tamoxifen produces an inhibitory effect on MCF-7 cell [3H]thymidine incorporation and DNA polymerase activity as well as causing a reduction in DNA content of cultures and cell numbers. This inhibitory effect of Tamoxifen UK on MCF-7 cell growth can be readily reversed by addition of estradiol to the culture medium. 2 and 6 μM Tamoxifen reduces the proportion of cells in S phase and increases the number of cells in G1. At 10 μM, Tamoxifen causes cell death within 48 hr. [2] Tamoxifen inhibits MCF-7 growth with IC50 of ~10 nM after 10 days treatment. Tamoxifen inhibits plasminogen activator activity of MCF-7, and suppresses estradiol-stimulation of plasminogen activator activity. Tamoxifen also evokes minimal increases in cellular progesterone receptor levels. [3] Tamoxifen is able to inhibit the growth of prostate cancer cell PC3, PC3-M, and DU145 with IC50 ranged from 5.5-10 μM, which is related to its inhibition of protein kinase C and induction of p21(waf1/cip1). [4]

Tamoxifen 20 mg for Sale UK

The pharmacological action of Nolvadex is characterized by the direct effect of the active component Tamoxifen 20 mg to the estrogen receptors in the affected organ or tissue. This drug includes a lot of the female sexual hormone estrogen. Tamoxifen inhibits the biosynthesis and secretion of estrogens which stimulate the growth of the tumor and neoplasms. It has been even found out that the more estrogen receptors are in the tumor, the faster and more effective this drug stops its development and the better the result of the treatment will be.

In spite of the big concentration of estrogens in Tamoxifen UK this hormone is not accumulated in the body and rather quickly excreted through the excretory system.

Tamoxifen 20 mg Dosage Cycle

The medicine is manufactured in form a tablet. Usually, it is recommended to swallow the tablet and take water with the medicine. The tablets might be produced in different strengths: 10mg, 20mg and 30mg.

Before use Tamoxifen 20 mg, you might want to know that the medication might be manufactured under various brand names. Sometimes, the medication might also be available as syrup for people who find difficult swallowing the medicine.

The medicine must be taken as a daily dosage, unless prescribed otherwise by your physician. The medicine must be taken each day during the period of the treatment. Some patients might feel discomfort while taking the medication. Tamoxifen has a metallic taste, so it is better to take it with food. Furthermore, the dosage of the tamoxifen may depend on numerous factors, including the following: additional medical conditions, other medicaments and the response to the following drug.
As with any medicament, you must not adjust the prescribed dosage unless your physician specifically directs the patient to do so. The physicians advise to take Tamoxifen 20 mg regularly to maintain the level of the drug in the patient’s blood. The medicine is to be taken as prescribed for best treatment results. Tamoxifen UK will not work if the patient stops taking it.

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